1A commercial and industrial city in central Connecticut, on the Connecticut River, south of Hartford, home to Wesleyan University; population 48,030 (est. 2008).
2An industrial city in southwestern Ohio, between Cincinnati and Dayton; population 51,422 (est. 2008).
Definition of Middletown in US English:
Middletown
proper nounˈmidlˌtoun
1A commercial and industrial city in central Connecticut, on the Connecticut River, south of Hartford, home to Wesleyan University; population 48,030 (est. 2008).
2An industrial city in southwestern Ohio, between Cincinnati and Dayton; population 51,422 (est. 2008).