An effect or property whereby the binding of a ligand to one site in a protein or other macromolecule alters the tendency of other sites in the molecule to bind further ligands.
Origin
1960s. From co-operative + -ity.
Definition of cooperativity in US English:
cooperativity
nounkəʊˌɒp(ə)rəˈtɪvɪti
Biochemistry
An effect or property whereby the binding of a ligand to one site in a protein or other macromolecule alters the tendency of other sites in the molecule to bind further ligands.