The pH release profile was generated in a variety of buffers (acetate, citrate, glucuronate, and phosphate).
After estrone hydroxylation, the various poly-hydroxy derivatives are conjugated with glucuronate or sulfate, or methylation occurs prior to excretion in urine.
Alternatively, a-tocopherol can scavenge two peroxy free radicals and then be conjugated to glucuronate for excretion in the bile.
Sodium glucuronate was used as the standard for quantitative evaluation.
The majority is conjugated to glucuronates and sulfates in the maternal liver permitting renal clearance.