Late Middle English; earliest use found in Geoffrey Chaucer (c1340–1400), poet and administrator. From post-classical Latin pythonissa (Vulgate), phitonissa woman with powers of divination from python-, pytho + classical Latin -issa.
Definition of Pythonissa in US English:
Pythonissa
noun
rare
Pythoness.
Origin
Late Middle English; earliest use found in Geoffrey Chaucer (c1340–1400), poet and administrator. From post-classical Latin pythonissa (Vulgate), phitonissa woman with powers of divination from python-, pytho + classical Latin -issa.